Getting To The Bottom Of The Causes Of Chronic Fatigue Syndrome
For years, researchers struggled to find clear-cut chronic fatigue syndrome causes. Perhaps it was just a convergence of factors, they surmised. It could be part genetics, brain abnormality, hyper-reactive immune system, a virus, infection and psychiatric illness. Scientists had a feeling this tiredness syndrome came about as a result of a moderate-to-serious physical illness or a chronic viral infection that left residual effects within the body. Perhaps depression helped perpetuate some of the symptoms for an extended period of time.
Are the chronic fatigue syndrome causes mental or physical? This uncertainty plagues every CFS sufferer who feels misunderstood by their peers. One aspect of the situation is the fact that there are no clinical tests to identify this disorder. Identification of CFS normally requires eliminating any other possible cause, which leads some to speculate that the disorder isn’t real. One thing that is recognized is that CFS patients experience intense fatigue and worsening of other symptoms right after even moderate physical activity. Through scientific investigation, it is hoped that researchers can answer some vital questions concerning CFS. Just recently, new links have been uncovered to shed some light on this mysterious ailment.
Earlier, the triggers of CFS were thought to have a genetic connection. Researchers observed that there were genes involved in the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system that were modified. These genes regulate a person’s reaction to trauma, injury and other stressful situations, so the abnormalities discovered could have conceivably affected immune system function, cell communication and cellular energy transfer. Patients with CFS have all sorts of gene variations, yet there hasn’t been a single gene established as responsible for the medical symptoms connected to CFS.
Another one of the proposed chronic fatigue syndrome causes has to do with abnormalities of the central nervous system and hormones. Abnormal chemical levels in the hypothalamus-pituitary-adrenal axis may be one cause of chronic fatigue medical symptoms, scientists have posited. For instance, some patients with CFS have abnormally high levels of seratonin (a chemical messenger in the brain) and abnormally low levels of dopamine (a neurotransmitter associated with sleep and feelings of reward). In other cases, CFS patients have imbalances between norepinephrine and dopamine levels or lower levels of the stress hormone cortisol. Fatigue can also be caused by a disturbed sleep-wake cycle, researchers add.
In October 2009, a team of researchers from the University of Nevada at Reno and the National Cancer Institute reported a definitive link between chronic fatigue syndrome and a virus called XMRV, which appeared in the vast majority of CFS patients they studied. The XMRV chronic fatigue virus is one of just three known retroviruses; the other two being HIV and HTLV. All three viruses are transmitted through bodily fluids. However, scientists are, at this point, cautious to point to a virus as one of the predominant chronic fatigue syndrome causes. “There’s been a tremendous interest in chronic fatigue syndrome. I’ve been getting almost nonstop calls from doctors and patients,” explains one of the head researchers, Robert Silverman from the Lerner Research Institute. “They’re obviously looking for hope in this study, although the virus is not proven to cause CFS. That’s still unknown. But until it’s ruled out, it’s going to obviously be a subject of great interest.”
If you have been recently diagnosed with chronic fatigue syndrome you are going to need to research the condition as much as you can. While you can treat the symptoms, the chronic fatigue syndrome causes are still largely unknown. Find out what you can do at Chronic Fatigue Syndrome Help.